Why thyroid optimization is so important!

The T3 and SHBG Relationship
The world of medicine and endocrinology continuously brings to light complex mechanisms that offer potential solutions to health concerns. One such interesting revelation pertains to the relationship between T3, a thyroid hormone, and SHBG (Sexual Hormone Binding Globulin) - and how it plays a role in abdominal obesity.

The Thyroid's Role in the Body
The thyroid gland, a butterfly-shaped organ located at the base of our neck, produces hormones vital to metabolism, growth, and development. T3 (Triiodothyronine) is one such hormone that has recently been observed to influence the levels of SHBG in the bloodstream.

The Connection to Abdominal Obesity
Individuals with abdominal obesity often exhibit low SHBG concentrations. This type of obesity isn’t just about the excess weight around the waist; it's linked with a higher risk of heart diseases, diabetes, and even certain types of cancers. The decreased peripheral conversion (deiodination) of another thyroid hormone, T4, into T3, might be a driving factor behind these low SHBG levels.

A Potential Treatment Paradigm
Given these revelations, the treatment paradigm for abdominal obesity may witness a shift. By treating patients with small doses of T3, we could potentially address some of the risk factors associated with this condition. This approach seems particularly promising for specific subgroups of obese men and women who display a relative resistance to thyroid hormones. Their bodies might not efficiently convert T4 to T3, making them ideal candidates for T3 supplementation.

Concluding Thoughts
In conclusion, the union between T3 and SHBG offers a promising avenue for exploring new treatments for abdominal obesity. While these findings, rooted in the 1997 study, provide a foundational understanding, most research is often overlooked. However, understanding these connections deepens our appreciation for the body's intricate mechanisms and their potential implications in treating health concerns. Normal is not optimal. . . thyroid hormone impacts so many systems and when these levels don't function as they should, you feel it. Jason and Rita...aka Dr. De Leon and Dr. Gillespie.

Source: Int J Obes Relat Metab Disord. 1997 Oct;21(10):922-9