Alzheimer’s Prevalence in Postmenopausal Women.

The biological mechanisms associated with higher tau deposition in female individuals is still not clear.  This study examined the extent to which sex, age at menopause, and timing of hormone therapy (HT) use are associated with findings of protein and plaque deposition seen with Alzheimer’s disease, measured with positron emission tomography (PET) scanning. In females, earlier age at menopause and late initiation of HT were associated with increased tau vulnerability especially when neocortical Aβ elevated. Coughlan GT, Betthauser TJ, Boyle R, et al. Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography.

JAMA Neurol. Published online April 03, 2023. doi:10.1001/jamaneurol.2023.0455.

Therefore, this clearly shows that the sooner perimenopausal and menopausal women start BHRT the better off they are in the long run with regard to their risk of developing Alzhemier’s disease. 

Jason & Rita