Polycystic Ovary Syndrome and Metabolic Syndrome

We reviewed Polycystic ovary syndrome (PCOS) in detail last week. It is an incredibly intricate and heterogeneous endocrine disorder that affects multiple bodily systems, including intermediate metabolism, cardiovascular and reproductive systems, and social and psychological well-being. Notably, PCOS is highly prevalent among women with Metabolic Syndrome (MetS), a group of metabolic disorders that elevate the risk of cardiovascular disease and diabetes.

A subtype of PCOS is the most commonly reported type, marked by insulin resistance, and ovulatory dysfunction. The development of this subtype is tied to central obesity, which can lead to a syndrome of insulin resistance and tesosterone for women excess, ultimately contributing to cardiovascular comorbidities.

Interestingly, the pathophysiological mechanisms of MetS and PCOS share many characteristics, suggesting that PCOS may be a complication of MetS or vice versa.

To explore this complex relationship further, this research paper investigates various aspects of these disorders, including their pathogenesis, infertility, microbiota, comorbidities, and treatment, with the aim of providing valuable insights into their management and treatment.

Salvidar-Ceron, H.I. 2023.  Relationship between Polycystic Ovary Syndrome and Metabolic Syndrome.  The Journal of Reproduction. 2(1): 5-14.

The interplay and potential causative nature of metabolic syndrome on PCOS is further magnified.  It’s amazing that so many say that PCOS needs to be re-named; I suppose the question is. . . how long will that process take?  In review of this paper, and others on the same topic; it seems clear that these two disorders could in fact be one in the same.

Jason & Rita