Impact of insulin resistance on the liver
As I peruse the literature, I finding it striking how frequently this link is addressed and "considered". It stares us in the face and yet changes are infrequently made to make our bodies more equipped to battle against this process.
Introduction
Non-alcoholic fatty liver disease (NAFLD) is not merely a term for physicians and health professionals; it is a looming global health issue. Characterized as the dominant cause of chronic liver disease, NAFLD is emerging as a formidable public health challenge that warrants immediate attention. Key to its development and progression is the association with elevated levels of insulin resistance (IR). Recognizing its gravity, this article delves deep into the relationship between IR and NAFLD and underscores the importance of early interventions to mitigate its dire consequences.
Methodology
An exhaustive review was conducted on several reputed databases - Google PubMed, Scopus, and Web Of Science, with data pulled till May 30, 2023. The search was steered using specific keywords such as IR, diabetes mellitus, Non-alcoholic fatty liver disease, and metabolic syndrome to ensure comprehensive results. The aim was to garner insights into the causative relationship between IR and NAFLD and its wider ramifications.
The IR and NAFLD Nexus
The accumulation of fatty acids in liver cells can be primarily attributed to IR. This accumulation stems from a rise in glycolysis and a concomitant decrease in apolipoprotein B-100. But NAFLD's clutches reach further than the liver. It becomes the precursor to a host of non-communicable ailments that have long-term impacts on an individual’s health. Conditions like diabetes mellitus, metabolic syndrome, polycystic ovary syndrome, obstructive sleep apnea, and even cardiovascular diseases have been closely linked with NAFLD.
Broader Implications and Treatment Approaches
While lifestyle alterations stand as the frontline defense against NAFLD, they often need to be supplemented with alternative treatment routes for better outcomes. The spectrum of these treatments ranges from pharmacological and herbal remedies to more intensive surgical interventions. It is heartening to note that by initiating these simple, yet potent, measures early on, devastating outcomes like cirrhosis, end-stage liver disease, and even hepatocellular carcinoma can be successfully thwarted.
Concluding Thoughts
NAFLD's association with elevated IR levels is undeniable. A mosaic of metabolic conditions, be it obesity, type 2 diabetes mellitus, dyslipidemia, or metabolic syndrome, converge to fortify this relationship. It is a clarion call for communities, health professionals, and individuals alike to escalate awareness about NAFLD. A collective endeavor to champion healthier lifestyles is not just advisable but imperative. Only through informed actions and cohesive efforts can we hope to reverse the tide against this stealthy assailant known as NAFLD.
Ziamanesh, F., Mohammadi, M., Ebrahimpour, S. et al. Unraveling the link between insulin resistance and Non-alcoholic fatty liver disease (or metabolic dysfunction-associated steatotic liver disease): A Narrative Review. J Diabetes Metab Disord (2023). https://doi.org/10.1007/s40200-023-01293-3
BHRT, changes to our diets, increasing our level of activity all lead to improvements in the relationship above. Allow us an opportunity to run your labs and show you how we can impact your future. Putting your health at the forefront is imperative. Jason & Rita...aka Dr. De Leon and Dr. Gillespie.
