Health-Related Quality of Life and Depression in Peri-Postmenopausal Women with Polycystic Ovary Syndrome: A Comparative Study

The Influence of Menopause on Women with Polycystic Ovary Syndrome

Perimenopause and postmenopause stages present unique health challenges for women with Polycystic Ovary Syndrome (PCOS). A fresh understanding of these challenges necessitates a thorough exploration of their Health-Related Quality of Life (HRQoL) and potential depressive symptoms. By analyzing the experiences of women in two age cohorts - 18 to 42 years and those aged 43 and over - we can begin to unravel these complexities.

Survey and Data Collection: Harnessing the Power of Social Media

Utilizing the global reach of Facebook, the study collected data via online questionnaires shared in two PCOS-focused groups. Of the 1,042 respondents, the majority were premenopausal (18-42 years old, n=935) with the remainder being peri or postmenopausal (≥43 years, n=107). This approach allowed for diverse data, encompassing numerous demographic variables and capturing the nuances of PCOS experiences across the lifespan.

Comparative Outcomes: Quality of Life and Depression in Different Age Cohorts

Upon analysis, significant differences emerged. Despite having similar number of comorbidities, older women (≥43 years) reported markedly better HRQoL than their younger counterparts. Furthermore, a significant positive linear association was observed between the HRQoL psychosocial/emotional subscale and other HRQoL subscales, while a negative association was noted with age. The fertility and sexual function HRQoL subscales, however, showed no significant link with the psychosocial/emotional subscale among older women. In terms of depressive symptoms, both groups reported moderate levels, highlighting mental health as a concern for women with PCOS regardless of age.

Implications and Recommendations: Tailoring PCOS Management to Life Stage

The findings underline the importance of life stage-specific healthcare for women with PCOS. Tailoring treatments and healthcare strategies can address specific challenges faced by these women. This includes focusing on mental health through requisite clinical screenings for depressive symptoms and lifestyle counseling across different life stages. This will provide valuable insights for future research on peri-postmenopausal women with PCOS, enabling a more patient-centered approach to healthcare.

Pamela J. Wright, Abbas S. Tavakoli & Cynthia F. Corbett (2023) PCOS health-related quality-of-life and depressive symptoms across the lifespan: Comparative study, Journal of Women & Aging, DOI: 10.1080/08952841.2023.2230112

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